The rationale of the potential role of CTp in predicting response to nonsurgical therapies is that it is substantially influenced by tissue perfusion and local oxygen delivery.
An intriguing rationale of the potential sensitization of non-M3 blasts to the effects of ATRA by pre-treatment with chemotherapy or azanucleosides has driven important lines of investigation.
Each of these has a specific rationale for potential use for amelioration of organophosphate-induced developmental neurotoxicity.
Furthermore, strong rationale for potential clinical applications of the described molecular mechanisms to the treatment of periprosthetic loosening and osteolysis is provided.
In the following lines, we will try to address strong rationale for potential clinical applications of the described molecular mechanisms for periprosthetic loosening and osteolysis treatment.
An exhaustively complete 2005 review paper by two of the current authors (Davison and Patel) in International Ophthalmology Clinics provided a detailed history, rationale for potential retinal photoprotection, correction of cyanopsia, and a possible improvement in contrast sensitivity by these IOLs [ 1].
Single-agent studies are typically employed to obtain hints of the potential activity of a new agent and to form a rationale for potential combinations.
In the following section we describe the rationale behind a series of potential metrics and evaluate their ability to discriminate between the TCSs of various organisms.
Rationale for our choice of potential confounders and for the categorisation of these are provided in appendix 2. Information on sex and age was obtained from population registries or interview (COPSOQ-I, DWECS, FPS, GAZEL, IPAW, PUMA, Still Working, WOLF Norrland, and WOLF Stockholm) or from questionnaires completed by participants (in HeSSup, POLS, and Whitehall II).
We discuss the rationale and potential of using Host-Directed Therapies for improving the poor treatment outcomes associated with MERS.
