One pathway that we are close to understanding the rationale of is that involving allergens that mimic the activity of helminth-derived products, particularly helminth-derived proteases.
The design rationale of these compounds involved the exchange of either the phosphonic acid or the hydroxamic acid part for alternative acidic and metal-coordinating functionalities.
The main rationale of this option involves deferring waste materials by switching mining activities from a high to low strip ratio pit.
Although the rationale of peer education involves the promotion of debate and dialogue amongst community members, with particular focus on obstacles to behaviour change and how these can be overcome, the community members felt the programme involved didactic messages on the importance of condom use.
Nevertheless, the mTOR-independent nature of the action of lithium and its cytoprotective and autophagy- inducing properties offer the possibility for the development of treatment rationales involving simultaneous lithium and rapamycin administration (Sarkar et al., 2008).
Parliamentary constituencies are fairly uniform in population size; part of their rationale involves an attempt to maximise their homogeneity.
And let's think about that for a second: Isn't it funny how whenever folks explain why they approve of gay censorship, their rationale always involves some gross metaphor like "shoving it down our throats," "sticking it in everybody's face" or "throwing it all over the room"?
33– 37, 58, 59 The rationale for hemilaminectomy involves preservation of the contralateral lamina, maintenance of the so-called "tension band", and maintenance of the integrity of the supraspinous/interspinous ligaments and the contralateral paravertebral musculature.
The dominant rationale involved release of neurochemicals (usually endogenous opioids [beta endorphins, enkephalins and dynorphins] or serotonin).
In addition, a key element for translating laboratory biomarkers into clinical applications, aside from the robustness of the scientific rationale involved, is the validation process.
