Our study has provided meaningful mode of action on the role of LDN in immunoregulation, and rationale on future application of LDN for enhancing host immunity in cancer therapy and potent use in the design of DC-based vaccines for a number of diseases.
Our study has provided more detailed data on changes of BMDCs modulated by IFN-α, and rationale on future application of IFN-α for enhancing host immunity and potent adjuvant administration in the design of DC-based vaccines.
Better understanding of immunological mechanisms of vaccination is expected to provide informative insights into the rationale design of future vaccines against difficult pathogens.
These findings lend support to the rationale of directing future exercise-based rehabilitation trials following hospital discharge to patients with ICU-AW, rather than using mechanical ventilation hours or ICU length of stay as inclusion criteria.
19 20 Assessment of efficacy and safety of CT-P13 in patients with RA for up to 1 year is ongoing, and the positive results of this study provide a rationale for future studies of CT-P13 in the treatment of other TNF-mediated inflammatory diseases.
Although only comparable clinical efficacy was shown in this study, clinical bioequivalence was investigated in a Phase 3 study in RA. 8 The positive results of this study provide a rationale for future studies of CT-P13 in the treatment of other TNF-mediated inflammatory diseases.
This unique mechanism of action provides an attractive rationale for future combination of Ang-(1 7) with other anti-angiogenic drugs.
The above observations would create a rationale for future evaluation of cabozantinib in earlier stages of prostate cancer, such as in the adjuvant setting for high-risk disease or hormone-sensitive disease.
Identification here of a direct association between α4β2∗ nAChRs and CaMKIIα provides rationale for future studies of its role in hippocampal plasticity.
These observations may provide a rationale for future treatment of RA with selective anti-TNF receptor instead of anti-TNF antibodies.
