Therefore, available data provide a rationale for exploring the value of such compounds to mimic the impact of cromolyn on gut permeability and performance of weanling pigs.
A recent study demonstrated that a small molecular inhibitor, PTC-209, is capable of inhibiting Bmi-1, further blocking self-renewal of colon cancer initiating cells (CICs) [62],[63], which provides a therapeutic rationale for exploring the efficacy of PTC-209 in targeting CSCs.
We summarized oncogenic function of NEK2A in Figure 2. The rationale for exploring the therapeutic potential of NEK2A is based on the observations described above that implicate NEK2A in various human cancers, contributing to tumorigenesis, tumour progression, and drug resistance.
Microglial activation can be detected in PD with C-PK11195 PET, and it provides a rationale for exploring the use of anti-inflammatory agents as potential neuroprotectants.
These results demonstrate that treatment with a soluble form of ActRIIA (ACE-011) enhances bone mass and bone strength in cynomolgus monkeys, and provide strong rationale for exploring the use of ACE-011 to prevent and/or treat skeletal fragility.
Therefore, there is a strong rationale for exploring the role of MDR1 polymorphisms in genetic susceptibility to DNA damage among pesticide-exposed fruit growers in our current study.
16, 17 Based on these findings there is a strong rationale for exploring the potential of macrophage-based therapeutics to improve outcomes after acute liver injury.
Thus, available data provide a rationale for exploring the value of bile acids and compounds that mimic their action as dietary supplements to improve performance of pigs under situations of increased incidence of enteric disorders.
The rationale for exploring the profile of atomoxetine in Parkinson's disease and predicted benefits following noradrenergic enhancement were predicated on the known longstanding noradrenergic dysfunction originating in the early degenerative events affecting the locus coeruleus.
Our data offer a scientific rationale for exploring the utility of Th17 cells, as well as Th17-associated molecules CCR4 and CCR6 as biologic markers for disease activity in human lupus.
