The rationale for enhancing autophagy using modulators of mTOR-dependent and mTOR-independent pathways may also be seen by the use of saturating doses of rapamycin with other mTOR-independent autophagy inducers.
These findings may be helpful in the development of AMP as a chemotherapeutic drug for breast cancer, and to the rationale for enhancing its anti-breast cancer efficacy by inhibiting protective autophagy.
Based on our findings from Phases 1 and 2, we drafted a set of nine recommendations with supporting rationales for enhancing the integration of evidence during the prenatal record review process across Canadian jurisdictions.
The results of cost effectiveness analysis provide a rationale to enhance the efficiency of resource allocation.
This activity provided the rationale for the development of thalidomide analogues with the goal of enhancing antineoplastic activity while reducing or eliminating thalidomide-associated side effects.
IMPACT: The beneficial effect of enhancing Tregs in ALS mice and the association of reduced Treg with faster disease progression and decreased survival in ALS patients provide an important rationale for enhancing Treg populations as a therapeutic option.
We have provided solid rationales for further clinical trials testing either examination of the bioenergetic propensity of HCC to predict the efficacy of sorafenib or activation of OXPHOS by PDK inhibitors as a measure of enhancing therapeutics efficacy of sorafenib.
Our findings, therefore, illustrate the potential potency of TD52 as an HCC therapy, disclose its mechanism of action, and also support the rationale of developing agents to enhance PP2A activity in future drug development for HCC and/or other malignant diseases.
Generally, patients cited many benefits, with the underpinning rationale that recording the encounter was a clear signal of empowerment, enhancing the value of the encounter, especially when permission was sought, thereby ensuring that clinicians were made aware of the process.
In this article I suggest that a reading of previous studies, which cast the early transfers of eucalyptus to South Africa along economic and aesthetic rationales can be enhanced by medical history.
