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The rationale of discovery-based high-throughput investigation of disease is that there are molecular signatures (composed of genes, transcripts, proteins, and small molecules) that can be identified for better diagnosis, prognosis, and/or treatment of disease.
A recent paper has described the rationale for and discovery of a new class of drugs - transcriptional noise enhancers - that can synergize with conventional transcription activators to more effectively reactivate latently infected T cells.
Furthermore, cancer-associated aberrations in glycan structures provide a compelling rationale for the discovery of new biomarkers through the isolation and identification of glycoproteins that contain these glycan structures.
Alternatively, in silico approaches in which compounds are docked to the structures of predicted targets have also been used in lieu of biochemical screening to generate rationale drug discovery leads.
"That moment of discovery".
Process of discovery.
They were terrified of discovery.
This is that process of discovery.
We're in this process of discovery".
So began the famed voyages of discovery.
It's a voyage of discovery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com