Sentence examples for rationale of developing from inspiring English sources

Our findings, therefore, illustrate the potential potency of TD52 as an HCC therapy, disclose its mechanism of action, and also support the rationale of developing agents to enhance PP2A activity in future drug development for HCC and/or other malignant diseases.

These results further cement the rationale of developing novel NCEs capable of modulating utrophin transcription as a potential therapy for all DMD patients.

The existence of functionally defective DC in cancer patients strongly emphasizes the rationale of developing DC-based immune therapy to restore proper presentation of tumor associated antigens and T cell activation.

But whether the same genes are involved in people as in lab rats isn't known, although part of the rationale for developing these strains of rats is to isolate genes that can be tested for in people.

We estimate that breast tumours are twice as likely to express high levels of P-Akt, providing further rationale for developing inhibitors of this pathway for the treatment of cancer.

We describe the rationale and concept of developing a Patient-Reported Outcome (PRO) tool to assess perceptions of symptom severity and expectations of therapy.

The original developers stated the rationale for developing this type of joint-specific instrument: it was expected to measure the impact of specific joint problems more precisely than global health assessment instruments, and also to be better in demonstrating the effect of a treatment directed at one joint only [ 1].

In addition, our data show that α-TEA not only enhances rapamycin suppression of mTOR and induction of apoptosis, but also suppresses rapamycin-mediated feedback activation of AKT, providing a rationale for developing a combination regimen of mTOR+ α-TEA for breast cancer treatment.

Likewise, much of the rationale for developing a routine was to "set the tone" and build a sense that students were expected to participate meaningfully throughout class.

The clear identification of the rationale for developing a risk score is critical to how its validity is assessed.

The rationale for developing inhibitors of TDP1 for subsequent combination with Top 1 poisons is similarly robust.