Sentence examples for rationale of combining from inspiring English sources

Moreover, both experimental (butyrate) and a clinically relevant HDACi (vorinostat) and liposomal doxorubicin (doxil) significantly reduced the viability of patient-derived primary myeloma cells, providing a rationale of combining this non-neurotoxic and steroid sparing combination for myeloma and other haematological malignancies.

With respect to the rationale of combining the three extracts a more potent neuroactivity of the triple combination compared to Hypericum alone and the additive effects of Passiflora and Valeriana suggested a synergy between constituents of these herbal extracts as derived from in vitro experiments with multielectrode neurochips [ 22].

More importantly, our study provides support for the rationale of combining CUDC-101 with modulators of ABC drug transporters to improve drug efficacy and overcome multidrug resistance associated with the overexpression of ABCB1 and ABCG2.

Richard Gonzalez, AbbVie's chairman and chief executive, said: "Although the strategic rationale of combining our two companies remains strong, the agreed upon valuation is no longer supported as a result of the changes to the tax rules and we did not believe it was in the best interests of our stockholders to proceed".

With the rationale of combining Bi3+ and Ga3+, we developed an oxide photocatalyst, Bi2Ga4O9 (loaded with RuOx), capable of overall water splitting under visible light due to its specific band structure, i.e., suitable potentials for valence and conduction bands, and most importantly its characteristic of anisotropic charge migration.

The rationale of combining rAAV with rAdv vectors is that a non-therapeutic dose of rAdv-null can greatly increase the transduction level of rAAV, and a combination of therapeutic dose of rAdv-Luc (2.5×109 pfu) and rAAV-Luc (1.5×1011 v.g).

A review on in vitro preclinical tests used to evaluate the effects of drug combinations and to design the rationale of combined chemotherapy protocols is presented.

In addition, leukemia-initiating cells (LICs), which are responsible for relapse of leukemia, could be cleared by ATRA/ATO based treatment in murine models, providing further rationale of combined use of the two agents (Au et al., 2001, Ito et al., 2008, Nasr and de The, 2010, Nasr et al., 2008, Zhou et al., 2010).

In this review article, we will primarily present the rationale for combining inhibitors of MGMT with TMZ to improve the efficacy of treatment for neurological tumors, particularly gliomas.

Therefore, there is a clear rationale for combining inhibitors of autophagy with other agents in clinical trials.

Collectively, these results provide a rationale for combining inhibitors of the JAK/STAT pathway and MEK inhibitors to reduce the potential impact of drug resistance.