Previous studies of β-catenin dependent mechanisms in immune tolerance provided the rationale for assessing the role of WNTs in IELs function.
Our findings indicate that IL13Ralpha2 could be used as a promising biomarker to predict patient outcome and provide a rationale for assessing the efficacy of anti-IL13Ralpha2 therapies in a subset of highly aggressive basal-like breast tumors as a strategy to prevent metastatic disease.
By altering the binding of at least two transcription factors, c-Jun and SP1, PI results in increased production of MMP-1 and decreased synthesis of type I collagen in human dermal fibroblasts, thus providing a novel rationale for assessing the potential of drugs targeting the proteasome for their anti-fibrotic properties.
Although many of the gene therapy approaches are in their infancy, the potential advantage that may be gained through the use of a hypoxia-mediated therapeutic provides a strong rationale for assessing the oxygen status of breast tumours prior to treatment.
Disease prevention was another rationale for assessing the effect of antibiotics on the endosymbiotic bacteria and, indirectly, on the ticks themselves.
The rationale for assessing the role of CD28 signalling in Th17 differentiation stemmed from reports demonstrating that treatment of experimental autoimmune encephalomyelitis (EAE) with anti-CD80 or anti-CD86 Abs or multiple injections of CTLA4-Ig resulted in enhanced disease severity [14], [15].
This provides a novel rationale for assessing the potential of drugs targeting the proteasome for their anti-fibrotic properties.
These observations formed the rationale for assessing the effects of ovariectomy on cartilage turnover and structural integrity in 5- and 7-month-old rats.
The rationale for assessing different doses of AS03 was to ascertain if lowering the dose could reduce vaccine reactogenicity without compromising immunogenicity, and the rationale for the booster dose was to assess the quality of the immunological memory created by primary vaccination.
To the best of our knowledge this is the first documented report on the effectiveness of nVNS using gammaCore on aura symptoms and, together with the experimental data cited above, it provides a rationale for assessing the potential effect of nVNS in the acute treatment of MA.
The present work, taken together with other recent studies (Netti et al, 2000; Pluen et al, 2001), begins to provide a rationale for assessing the relative penetrability of different tumours depending on the tumour type and the site of growth.
