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The rationale of adding a tert-butyl carbamate group (converting the compound into NB7M; Figure 1A) was to protect the amino group in the hope of increasing the bioavailability as the lipophilic protection of a nitrogen atom in various anticancer drugs enhances tissue permeability (Serova et al, 2007).
They should also explain in the main text why they think that all four components need to be added to observe microtubule bundling, whether the HIS-tags present on the individual proteins can contribute to microtubule bundling and also explain the rationale of adding ch-TOG in sub-stoichiometric amounts compared to the other components.
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Part of Dr. Howard's rationale for adding cancer to the list of eligible illnesses was that the dust, smoke and fumes were known to contain potential carcinogens like asbestos, silica, benzene, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, volatile organic compounds and metals.
Our rationale for adding this richness of medical details was partly to explore the boundaries between a coordination support system and other clinical information systems, and partly to augment focus on the privacy aspect of accessing detailed clinical information on a digital whiteboard in a non-restricted area.
Still, said Tommy Roy, executive producer of NBC Sports, it fits his rationale for adding a toy.
In conclusion, this study clearly supports the rationale, safety and efficacy of adding a single dose of insulin glulisine to ongoing insulin glargine plus OHAs to improve HbA1c and mean daily plasma BG when HbA1c targets have not been met.
But as Chief Justice John G. Roberts Jr. pointed out, the Federal Circuit had a rationale for adding its distinctive gloss to the concept of obviousness.
There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.
The Justice Department's original rationale for adding the question also got weaker during the trial.
The rationale for adding epinephrine to reduce the maximum plasma concentration is local vasoconstriction at the site of injection [ 3], thereby slowing absorption.
The rationale for the addition of LV to UFT follows that of adding LV to 5-FU.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com