Although it is the simplest and the most widely used practice that regards a pathway being up-regulated if the mean expression is positive and down-regulated if negative, such a rationale lacks solid biological support.
I have been beyond baffled at the bizarre rationale (or lack thereof) used to defend this movement to save Roman Polanski -- including on this very site.
If it does not or will not, its major rationale will lack ground, and therewith, it may not be able to reach the morally required balance of benefits and risks.
Perhaps investors are simply as confused as Lukas Podolski, a German football player who described the game as "like chess, only without the dice".The usual explanation for sharp price movements, when an economic rationale seems lacking, is that someone is selling off their holdings at any price.
We conclude that among other possible rationales, a lack of courtroom guidance, a defensive posture and a marketing exercise in standard expansion may explain the force of the text that we found.
It appears that the necessity of simultaneous amplification of complementary strands of double-stranded DNA can justify the existence of tandem replication complexes in the case of DNA polymerase; this rationale is lacking in the case of RNA polymerase, which utilizes only one DNA strand as a template.
When Standard & Poor's downgraded U.S. government debt last summer, the rationale was a lack of faith in American politics.
Studies conducted in the presence of seminal plasma and with postcoital sampling may provide a biological rationale for this lack of protection [1], [2], [3], [4].
The third rationale was a lack of 'obvious' or worrying symptoms, such as bleeding.
14 15 16 17 18 The rationale given is lack of evidence, no benefit, or risk for adverse events, mainly colitis associated with Clostridium difficile and induction of antibiotic resistance.
The latter observation agrees with previous studies that reported the highest production of recombinant AS at 37°C [ 12, 21]: the rationale for the lack of temperature dependence is probably an effect of the small size of the investigated protein [ 22].
