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The rationale is further supported by the GRP78 knock-down study, in which down-regulation of GRP78 increased the ratio of Ser473/Thr308 by elevating Ser473 phosphorylation without affecting Thr308.
This rationale is further described below.
This rationale is further strengthened by the fact that EGFR overexpression is associated with worse prognosis 1, 2 molecule consists of an N terminal, extracellular, ligand-binding domain; a hydrophobic transmembrane domain; and a C-terminal intracellular domain with tyrosine kinase activity.
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The rationale of using ΔKeff is further demonstrated through fractographic investigations.
The clear floristic distinction between alien and invasive plant taxa in the EUS, and the strong biases in habitat representation between invaders of different origin and life history attributes, is further rationale for more careful delimitation of the focal species pool in invasion studies [23].
The rationale of such investigations is further supported by recent reports of the inhibition of growth, or induction of apoptosis, of prostate and astrocytic tumors following drug inhibition of LSD1 in in vitro and in vivo preclinical models [ 17, 18].
A variety of different evaluation approaches for OHIs have evolved, which either focus on specific aspects of interventions to be evaluated or present general rationales to be further specified and operationalized in regard to a specific project [ 2, 7, 8].
Furthermore, we put forward some specific research questions about design rationale that could be further investigated to benefit industry practice.
Further rationale is provided below.
Further rationale is provided by the costs of administration and burden for other reporters.
Further, this rationale is consistent with the idea that PBP2A is not the sole determinant for β-lactam resistance in MRSA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com