The rationale for this is associated with the fact that specific antibodies raised to ovarian FSH cross reacted and neutralized the activity of FSH of variety of species including humans.
Motivated by the same rationale that genetic variation that is associated with both the trait and gene expression is more likely to be biologically relevant than variants associated with the trait only, we mapped GWAS loci to CD4+ coexpression modules and examined the modules that were tagged by GWAS loci.
Rationale: In patients with TBI, hyperthermia is associated with higher mortality rates [63, 64], unfavourable neurological outcome [63 66], and prolonged length of stay in the ICU and in the hospital [63, 67, 68].
Rationale: Early and adequate antimicrobial therapy is associated with increased survival in patients with severe sepsis and septic shock [ 19 ].
For this reason, until microarrays became available, association studies focused on specific candidate genes, that is, genes that have some rationale for being associated with the trait.
Some interventions, albeit based on a seemingly sound rationale, have even been associated with patient harm.
44 Conclusively, a strong biological rationale behind bisphosphonates being associated with worsened stroke prognosis is lacking, which is in agreement with our null result.
1 2 The opportunity to block the renin-angiotensin system at multiple foci has a compelling biological rationale but may be associated with significant toxicity.
Management factors and other variables of interest were identified in the dataset based on an a-priori rationale that they were associated with MAP antibodies in milk (Table 1).
Implementation of a rapid response team (RRT) in which clinical judgment, in addition to vital-signs criteria, was widely cited as a rationale for activation was associated with an 11% decrease in hospital-wide mortality.
