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However, it is important to caution that any attempts in women to alter Treg cell number or function during or prior to pregnancy must be based in a sound biological rationale, informed by knowledge of the antigens against which pregnancy-associated Tregs are normally targeted, and taking into account the natural ontogeny, timing of activation and regulators governing these cells.
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A similar rationale informed the training programme for practitioners: simply advising them to change their way of consulting is ineffective.
Besides this economic rationale, seasonal nomadism is informed by many refugees' desire to enjoy a nomadic life in the badiya (Volpato and Rossi [2014]).
Refugees' use of the liberated territories and northern Mauritania (where the Sahrawi have free informal access) for pasturing herds is informed by an economic rationale related to the emergent markets for livestock and livestock products in the refugee camps, as camel herds spend fallow or fattening periods in free-grazing conditions in these regions.
The rationale for dampening inflammation has been informed by the efficacy of most anti-mycobacterial drugs against actively replicating Mtb and their limited activity against dormant bacilli.
All students included in the survey were informed by a physician about the rationale and aims of the survey, and a written informed consent was obtained.
Despite the fact that the rationale for any successful health interventions should be informed by the cause of deaths (CODs) that are of the greatest importance locally, many developing countries lack this crucial information (1).
Eligible subjects were informed by a physician about the rationale and aims of the survey and all those who were included provided a written informed consent; personal information was protected according to Italian law [ 28].
They were then provided with a summary of current evidence about rehabilitation, current practice in the United Kingdom (informed by the survey results) and the rationale for future research.
The rationale for using a conservative estimation of NTHi pneumonia incidence was informed by the considerable variation amongst estimates reported in the literature [ 30- 34].
The rationale concerning the choice of adjunctive medications for residual symptom treatment was informed by various adult data in bipolar I and II disorder, as well as limited data that exist in children and adolescents with bipolar disorder (for a review, see Smarty and Findling 2007) [ 14].
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