Sentence examples for rationale in the setting of from inspiring English sources

IGF-1R inhibition is supported by biologic rationale in the setting of trastuzumab resistance due to receptor crosstalk, but mature clinical data are lacking.

The scientific rationale for testing such antagonists in the setting of lung fibrosis is gaining strength.

The primary rationale for administering colloid solution in the setting of hypovolemia is the desire to expand plasma volume more effectively and extend the treatment duration.

This intuition contributes to our rationale for tolerating greater adverse event risk in the setting of secondary prevention of certain diseases such as myocardial infarction or stroke.

As both DR4 and DR5 agonists are under clinical development our results provide a rationale for the use of the latter in the setting of HCC in clinical practice.

5-aza-2′-dC is used clinically in the setting of hematologic malignancies with the rationale of reactivating silenced genes [ 19].

In this review we provide an evidence-based rationale for the incorporation of novel technologies for transurethral resection of bladder tumor in the setting of previously set standards.

This rationale might also be valid for the setting of our study.

Collectively, these data underpin the rationale for the present set of experiments to identify the presence of functional α4δ-GABAARs and tonic inhibition in the MGB.

The rationale for randomly sampling blocks rather than individual columns was to effectively vary the set of representative proteins as in [ 44].

In addition to gathering information on experts' uncertainty distributions for the set of questions, we asked experts to explain their thinking and provide rationales for their assessments.