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The potential for NO to have beneficial effects has provided the rationale for trials of administration of NO donors in various diseases.
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This is of significant concern and forms the rationale for trialling a different approach to preventing excessive weight gain in obese women.
However, discussing such scientific rationales for trials might disrupt the focus of consultations about the child's treatment and therefore discourage trial participation.
These results provide the rationale for clinical trials in early breast cancer to test the clinical utility and benefit of ctDNA monitoring.
Inconclusive results from adjuvant trials of the oral bisphosphonate, clodronate, in the 1990s formed the rationale for adjuvant trials of the more potent ZOL.
Our results in the context of prior studies provide a strong rationale for larger trials that are adequately powered for smaller effects on urine albumin excretion or trials that are conducted in participants who take ACE/ARB therapy.
It defines and explains the rationale for such trials.
Such a cohort study would improve the evidence base and (if justified) provide the rationale for controlled trials.
Conclusions: These results call into question the importance of oxidative stress in the disease and the biochemical rationale for clinical trials of antioxidants to prevent and treat preeclampsia.
Taking into account neuroprotective potentials of propentofylline, results offer additional rationale for clinical trials investigating efficacy of propentofylline in treatment of acute stroke.
While these certainly are significant obstacles (as it was pointed out earlier, the operation of the ICTY was almost undermined by such difficulties), they do not challenge the rationale for using trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com