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By visualizing the position of the substituted amino acid, the other amino acids in the immediate environment, and the proximity of the substituted amino acid to the substrate and the cofactor, it is possible to suggest a physiochemical rationale for the effect, or the lack of any effect, of the substitution on enzyme kinetics as determined by the experiments of Takahashi et al.[4].
The recently determined eubacterial and aracheal OST homologue structures afford an opportunity to glean a structural rationale for the effect of the middle X residue on co- and post-translational N-glycosylation.
Similar(58)
Given that it was unclear what the clinical rationale for the effects explored was within each of the clinical effectiveness models and that the need for a further RCT exists, designing this study will be complex when uncertainties exist at this level.
Moreover, a design model is proposed to provide a clear rationale for the effects of transverse-steel on the shear contribution of FRP.
The rationale for the effects of deworming programmes on population development depend on the assumption that they improve nutrition, haemoglobin, and cognition.
We have also attempted to provide structural rationale for the effects of known cardiomyopathy mutations and anticipate important regions which will be vital for its structural states and functional consequences.
There is some biologic rationale for this effect, since the mechanism of action for bisphosphonates is inhibition of osteoclast activity.
Disease prevention was another rationale for assessing the effect of antibiotics on the endosymbiotic bacteria and, indirectly, on the ticks themselves.
Furthermore, these results can be a rationale for studying the effect of taxane treatment in cancers with CHFR inactivation.
We can think of no rationale for why the effect of censoring on statistical power would differ between the two designs.
What is the rationale for testing the effect of an extended culture to Day 3 before sorting, and was there a parallel culture of "FGF2 only" to Day 3? We have read this submission.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com