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We are undertaking further SAR studies on our cis-Apc-substituted peptides using NMR and theoretical molecular modelling methods to provide structural rationale for the activity results.
The triplicate data also provided us with the opportunity to evaluate the rationale for the activity assignments based on curve class.
The current manuscript reviews the background and rationale for the activity of bevacizumab in RCC, and results from recent clinical trials with this agent alone or in combination with targeted agents or cytokines.
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If you require your child to do something, provide a rationale for why the activity is useful, important, and valuable to them.
In vivo nascent polypeptide chains represent the putative primary target of ADEP-activated ClpP, providing a rationale for the antibacterial activity of the ADEPs.
These findings provide a structural rationale for the observed activity of synthetic peptides based on these NT regions.
Overexpression of PDGFR in some STS (Yoon et al, 2006) further supported the biological rationale for the antitumour activity of sunitinib.
These findings provide a rationale for the antitumour activity and the cell cycle effects of a combination of SU11274 and SN38.
The permanence of a sufficient drug concentration or of a measurable effect has been evaluated in different tumour types and provides a rationale for the antitumour activity observed (see Tables 1 and 2 for details).
The rationale for the increased activity of mut-1 with C/EBPβ-LIP expression vector has not been discovered yet as we failed to show the direct binding of C/EBPβ on this site.
Reporting of the rationale for the chosen activities, any tailoring or modifications of the activities and measures of planned and actual activities carried out during the trial (eg, attendance at training sessions) were the least frequently reported.
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