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Our results provide a rationale for testing a hypothesis that early therapeutic vaccination (e.g., within two months p/s) may prevent reverse mutations and reduce viral set point.
Overall, these data demonstrate that vaccination with chemically attenuated parasites induces protective immunity and provide a compelling rationale for testing a blood-stage parasite-based vaccine targeting human Plasmodium species.
The rationale for testing a dopamine 3 agonist in fibromyalgia is based on evidence that excessive adrenergic arousal may fragment sleep, and enhancement of dopaminergic neurotransmission at the D3 receptors in the mesoliombic hippocampus may reduce expression of arousal and improve sleep.
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The rationale for testing an antivascular approach in ovarian cancer is highly appealing.
The rationale for testing an additive genetic model was to test the effect of zero vs. one vs. two minor alleles on BMI status and obesity intervention outcomes, which is usually the best choice if the true genetic model is not known [ 28].
Furthermore, these data provide a rationale for testing elafin as a prognostic marker in a prospective study.
The rationale for testing patients in a dopamine depleted state (off medication) was to quantify the effects of more pure basal ganglia impairment on anticipatory grasp control than would be the case with medicated patients.
In general, the detailed characterisation of the biological properties of a particular pathophysiological factor could provide a logical rationale for testing its potential prognostic significance as a biomarker in HCC.
In conclusion, these data provide a platform for further investigation and a rationale for testing the effects of manipulating vascular permeability during chemotherapeutic intervention.
What is the rationale for testing the effect of an extended culture to Day 3 before sorting, and was there a parallel culture of "FGF2 only" to Day 3? We have read this submission.
What is the rationale for testing the effect of an extended culture to Day 3 before sorting, and was there a parallel culture of "FGF2 only" to Day 3? Inconsistency of experimental data Data shown in Fig 3D indicates that T + clones contain 2 and 4 cells (the majority) with a few having up to 6 cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com