This study provides further rationale for targeting Mst1r as a therapeutic strategy.
Kagey, M. H. & He, X. Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology.
SETDB2 knockdown enhances sensitivity to kinase and chromatin inhibitors, providing a mechanistic rationale for targeting SETDB2 therapeutically in ALL.
Giltnane, J. M. & Balko, J. M. Rationale for targeting the Ras/MAPK pathway in triple-negative breast cancer.
An appeals court nonetheless released a redacted version of a long-secret Department of Justice memo that lays out the legal rationale for targeting American citizens overseas.
Our findings also provide rationale for targeting the PD-1 pathway in the adjuvant therapy setting of head and neck cancer following surgical resection.
Altogether, our findings uncover a GBM-promoting role of NR1D2 and provide the rationale for targeting NR1D2 as a potential therapeutic approach.
We will focus on the biologic rationale for targeting novel pathways regulated by Bcl-6, Bcl-2, BLysS, and APRIL for example.
Taken together, these findings provide strong rationale for targeting the BMM in BCR-ABL1+ pre-B ALL, with zoledronic acid identified as a potential therapeutic candidate for clinical application.
Having established a basis for exploring ATP-competitive mTOR inhibition as a potential novel anti-fibrotic strategy, we focused on establishing a human-disease-based rationale for targeting this axis in the context of IPF.
Bou-Dargham, M. J., Khamis, Z. I., Cognetta, A. B. & Sang, Q. A. The role of interleukin-1 in inflammatory and malignant human skin diseases and the rationale for targeting interleukin-1 alpha.
