We identified 22 items relating to the structure of the model and broadly classified them into 10 domains: 1) statement of decision problem/objective; 2) statement of scope/perspective; 3) rationale for structure; 4) structural assumptions; 5) strategies/comparators; 6) model type; 7) time horizon; 8) disease states/pathways; 9) cycle length; and, 10) parsimony.
The rationale for the model structure, the statement of scope/perspective, and the structural assumptions were not clear.
The quality appraisal instrument devised by Philips et al. [ 24] include dimensions of methodological quality corresponding to rationales for structure, structural assumptions, disease states/pathways, cycle length, and internal consistency.
Another lawyer who works in Jersey's trust industry, looking after assets of overseas millionaires, explains over a beer that local rules mean he must know the commercial rationale for the structures he administers.
However, neither the rationale for the model structure nor the structural assumptions were sufficiently clear.
DFT studies of TpCoCO permit detailed comparisons of theory to experiment, and a rationale for the structure that applies to unstable species as well.
The identification of conserved residues within ACE and their role in inhibitor binding has highlighted several important features required for ACE inhibition, providing a rationale for the structure-activity relationship of ACE inhibitors.
"The principal stated rationale for the changes in the structure of executive pay in the UK over the last three decades has been a desire to align the incentives of managers with the interests of shareholders.
In this study, the primary decision-maker was not specified, and the rationale for the model structure was less clear.
To achieve this objective quantitative structure activity relationship (QSAR) studies were carried out as it provides the rationale for the changes in the structure to have more potent Aβ42 inhibitors or anti-Alzheimer's agents.
