Exact(2)
The rationale for searching differentially expressed genes for common TFBS is the assumption that co-expressed genes are coordinately regulated by a limited set of TFs.
The isolation of this strain, which is pathogenic, but lacks the QS-regulator LasR and its cognate autoinducer 3O-C12-HSL, constitutes a challenge to the current model for explaining the mechanism of P. aeruginosa virulence, and to the rationale for searching compounds that inhibit LasR activity as a means to treat infections caused by this bacterium [ 33].
Similar(57)
The rationale for search strategy, inclusion and exclusion criteria is presented in the section 'search strategy and sample'.
Interestingly, on the basis of our predicted annotation, this gene could be involved in the synthesis of C21-steroid hormones, thus providing a strong rationale for its potential involvement and for searching variants of its sequence in obesity.
The rationale behind searching for differentially expressed proteins between a strain belonging to LAM and a strain to Haarlem families was to find proteins that could explain the differential innate/adaptive immune responses developed by these two families [ 26– 28].
To our knowledge no such proteins have been described to date, but our findings provide a rationale to begin searching for plant-produced inhibitors of this enzyme.
"You're absolutely right that we don't do a proper record on the street which details the rationale for the search, which piece of legislation was used, the officer's name and details," Mawson said.
We believe this to be an important observation as it gives a strong rationale for the search of the new stress-related biomarkers via network analysis.
The dual function of TGR5 in biliary bicarbonate secretion and Kupffer cell inhibition along with findings in previous genome-wide association studies provided a strong rationale for the search for novel genetic variants of TGR5 in PSC.
Findings from this study implied the molecular mechanisms underlying high level protection induced by UV-attenuated cercariae vaccination and would lead us to a rationale for the search of antigenic epitopes for the stimulation of specific T cells, and significant antibody isotype as well as cytotoxicity.
The rationale for these searches was that the presence of these genes in anemone suggests their presence in coral, and their successfully identification in the coral larval transcriptome would support the completeness of this sequencing effort.
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