If options are backdated, the receiver has an instant profit and even less incentive to move the company forward in the long run the rationale for options in the first place.
10, 12– 18 This review of the literature, in addition to summarizing opinions from recently published guidelines and studies, elucidates the pathophysiological characteristics of elderly patients with type 2 diabetes mellitus (T2DM), and discusses the rationale for selection of current options in managing this patient population.
The six treatment options (as well as the step 1 option of watchful waiting), the rationale for treatment selection within stratified stepped care and the care provider responsible for each treatment option are displayed in Table 1.
The rationale for the surgical option was based on the fact that more than 85% of ovarian malignancies are epithelial in origin and most of these cancers are cystic.
The rationale for the latter option is: At this prior time, a safety expert reviewed the SDR including its scores, the available ICSRs and further safety information, e.g. scientific literature, and made a point-in-time validation decision ("signal" or "no signal").
For this reason, there is a growing consensus that the inhibition of combined components in the PI3K-Akt-mTOR pathway likely reflects a mechanistic rationale for the therapeutic options.
The rationale for such a treatment option is sound.
However, the failure to completely normalize fasting hyperglycemia in patients with type 2 diabetes appears to be consistent with both clinical practice and previous clinical studies (14) and provides a rationale for adding complimentary treatment options, such as short-acting insulin (24) or incretin-based therapies (25), if normoglycemia cannot be achieved with basal insulin alone.
The rationale for this treatment is that option awards are not a cash expense and that the potential dilution if the options are exercised is duly noted in diluted earnings-per-share figures.
The rationale for employing a forced choice is that although an opt-out option can reduce biases in parameter estimates, it cannot provide sufficient information on respondents' preferences for the attributes if many respondents choose the opt-out option [ 9].
This commentary explores the rationale and options for engineering a use-dependent blocker of Cav2.2.
