The structural modification of gatifloxacin and the rationale for the modification is summarized in Schemes 1 & 2. 1,4-dihydroquinoline-3-carboxamide (4 12) and 1-4-dihydroquinoline-3-carbohydrazine (13 14) analogues of gatifloxacin, formation proceeds via the usual pathway of nucleophilic substitution (Scheme 1).
The rationale for this modification is based on three key points.
The rationale for this modification is to give more importance to those genes that, being annotated in a functional module, are positively correlated to the main bulk of genes in the module.
Although there do not appear to be sequence motifs common to proteins ubiquitinated by Parkin, it seems that the rationale for the modification of proteins is actually very simple.
It is now condemned as unscientific by Popper because the only rationale for the modifications which were made to the original theory was to ensure that it evaded falsification, and so such modifications were ad hoc, rather than scientific.
Curran and Hayashi refer to the Readiness for Interprofessional Learning Scale in their article yet rename the instrument as "Attitudes towards Interprofessional Education" and give no rationale for the modifications made.
The health care team should take care to explain the rationale for treatment modifications (i.e. that there is a need to find a balance between tolerability and the most effective dose).
Upon any modification or redesignation of existing degree granting authority, the Secretary of Defense shall submit to the Committees on Armed Services of the Senate and House of Representatives a report containing the rationale for the proposed modification or redesignation and any subsequent recommendation of the Secretary of Education on the proposed modification or redesignation.
The rationale for the N-terminal modification was that the dipeptide Met-Gly at the N-terminus of scFvG2/p17 represented a N-myristoylation signal which would promote the addressing scFvG2/p17 to the same compartment as the N-myristoylated MAp17 protein and Pr55Gag polyprotein.
The rationale for inducting this surgical modification was based on the fact that, by preserving the verumontanum at the apex of the prostate, we preserve important anatomical structures that pass nearby that area and may play a role in the continence mechanism.
Our rationale for making these specific modifications included removal of the phenyl group at position 3 (R) to eliminate a chiral center and simplify the structures.
