Sentence examples for rationale for implicating from inspiring English sources

The rationale for implicating these findings to pathophysiologic neurotoxicity in METH abusers evolved from the fact that these cells are primary human brain cells.

Furthermore we show that phosphorylation of PLCγ, ERK and AKT are all dependent on Zap70 catalytic activity, suggesting that the LAT signalosome and PLCγ are required for ERK activation in CTL, providing a rationale for previous observations implicating both ERK (Robertson et al., 2005) and PLCγ (Le Floc'h et al., 2011) in CTL-mediated killing.

Alternatively, as there is a strong biological rationale for investigating markers implicated in vascular pathologies, many markers such as the soluble intercellular adhesion molecule-1 (sICAM-1), the soluble vascular cell adhesion molecule-1 (VCAM-1), the e-selectin or the thrombomodulin have been identified and seemed to correlate with disease severity [ 15].

Despite support for a homogeneous Pr ground state, ongoing studies of the cyanobacterial phytochrome Cph1 from Synechocystis sp. PCC6803 implicate its heterogeneity, providing the rationale for the investigation presented here.

Distrust of the national government, implicated in the regional conflict, appears to have constrained the control effort with respect to suspicions about the rationale for rapid and isolated burial and beliefs such as those that implicated Ugandan government forces in the origin of the outbreak.

For now, the intriguing findings of Connelly and colleagues [ 1], as well as other published findings implicating SEPT9 in cancer, translate into a compelling rationale for more intensive studies of septins in cancer.

Moreover, the normative issues implicated by certain coercive laws are so complex and contentious that any rationale for or against these laws will include claims that can be reasonably rejected secular or religious as the case might be.

appear to be implicated in the pathogenesis of DSPN (10, 64), there is a good rationale for management of vascular risk factors beyond glycemic control.

Thus, there is considerable theoretical rationale for level of goal/action identification influencing self-regulation in clinical contexts, with a concrete level-of-identification implicated in poorer resistance to temptation.

These data implicate the PI3K/mTOR pathway as a key mediator of tumor metastasis and reveal a novel rationale for application of catalytic-site PI3K/mTOR inhibitors in cancer therapy.

Even though the rationale for treatment failure is not fully comprehended, co-factors to the ER α such as cyclin D1 might be implicated in the process, theoretically blocking tamoxifen response.