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Our current finding coupled with other recent observations provides a strong rationale for identifying brain permeable c-Abl inhibitors with optimal pharmacodynamics properties to slow down the progression of PD and potentially other degenerative diseases.
When performing indirect comparison or mixed treatment comparisons a rationale for identifying and selecting studies should be presented together with an assessment of quality and heterogeneity (Section 5.2.12 to 5.2.18 GMTA; Section 5.7.2 SMSE STA).
First, there is a strong rationale for identifying HIV-1 peptides presented by distinct MHC class I molecules that may be recognised by T cells and/or NK cells in vivo.
Increasingly, there is a rationale for identifying biological markers of drug responsiveness.
Substantial epidemiological evidence has provided the rationale for identifying prolonged workplace sitting time as an emerging public health concern.
For example, the rationale for identifying peak AA, as seen in Table 1, was: Altenusin C15H14O6 was from Alternaria and thus taxonomically unlikely.
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In the case of bioenergy grasses, this is strong rationale for first identifying a causal genetic lesion in a diploid genome (e.g. sorghum) and then testing the effect of the mutation in more complex genomes through plant breeding or transgenics.
The challenge is therefore to develop a methodology that accurately identifies these unique resource needs, uses an approach that is acceptable to the disabled community, enables all disabled people to participate, and distinguishes 'needs' from 'wants.' This paper describes and presents the rationale for a mixed methodology for identifying and prioritising the resource needs of disabled people.
This study has provided a clear rationale for the further development of methods for identifying barriers among Colombian PTs.
It then examines the rationale for reframing, first identifying the problems with the current frame obesity before exploring the benefits of the proposed frame caloric overconsumption.
Research approaches and rationale focused on identifying botanicals/biologics for prevention and therapy that target the stem cells were presented [ 43].
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