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Based on available data, we provide a rationale for identification of molecular targets for synaptic protection in neurodegenerative disease that accompanies HIV-1 infection of the nervous system.
Here, we describe the rationale for identification and validation of a new class of drugs termed senolytics, which selectively kill senescent cells.
Another rationale for identification testis and epididymis-specific methylated promoters is the high contribution of releasing or secretion of these organs to cfsDNA concentration.
These findings provide a rationale for identification of mechanisms to increase utrophin protein stability or translation as a means to increase utrophin protein expression, in addition to current strategies to identify methods of augmenting utrophin transcription.
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Researches in this regard provided the theoretical rationale for the identification of bed separations and bed-separation water, as well as effective containment of bed-separation water hazard.
This chapter covers linking requirements up to the source from which they sprang, a rationale for their identification, and requirements for other elements with which they are related.
Thus, there is an important clinical rationale for early identification and for adequately treating DM patients with nail alterations.
We provide a detailed discussion of our rationale for the identification of outliers and their characteristics [see Supplemental Material for details (http://www.ehponline.org/members/2009/0800312/suppl.pdf)].
This would provide important rationale for the identification of genes or transcripts being located in QTL intervals associated with milk production traits.
We report here a compelling rationale for the identification of a PI polyamide that inhibits a part of E-box-mediated MYC downstream gene expression and is a model for showing that phenotype-associated MYC downstream gene targets consequently inhibit MYC-dependent tumor growth.
The convergence of results for these cis and trans experiments suggests that Myb protein functionally activates the cardiac enhancer of at least one heart gene, thus providing a plausible rationale for the identification of Myb motifs as positive discriminators in the classification of CC, PC and heart enhancers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com