Further, our studies provide a strong rationale for critical examination of the mechanistic relationship between Akt activation and MPTP toxicity.
Although the more subjective factor of RAP was frequently present in both cases (36%) and controls (38%), it was rarely the sole rationale for GI examination in either group (1 of 25 cases, or 4%; 2 of 13 controls, or 15%; P = 0.27).
In summary, the present work provides behavioral evidence and a physiological rationale for further examination of the role of neurotrophins, and BDNF in particular, in locomotion.
Within the three studies reviewed here, the primary rationale for the examination of cognitive outcomes was to document any adverse effects of cochlear implant surgery itself on global intellectual ability.
The inclusion of CRT in therapeutic DNA vaccines has been demonstrated to successfully promote the generation of antitumor immune responses in HPV-positive tumor models [ 20- 22], justifying our rationale for the examination of anti-MCC immunotherapy with a DNA vaccine encoding CRT linked to the LT antigen.
Closer examination of the pathways identified will be necessary to provide a rationale for testing inhibition of specific targets in combination with SINE compounds to enhance the activity of SINE compound mono-therapy.
The rationale for testing DHA was strong.
These good outcomes must be weighed against the cost of MRI, the high rate of short-interval follow-up and biopsies generated, and the lack of a clear rationale for using the examination for follow-up.
Such information can provide a rationale for the fitness-to-drive examination and help policymakers and clinicians conducting these examinations.
We hypothesised that the finding of prevalent conditions in commercial drivers that can be associated with increased risk of crashes and can be readily diagnosed would provide the rationale for the fitness-to-drive examination.
