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However, the analyses relate to one secondary efficacy outcome (relative risk of ≥ 10 letter gain at 12 months), not the primary efficacy outcome in any pivotal phase III study of IVR or IVT-AFL (mean gain in BCVA at 12 months in VIVID-DME/VISTA-DME), and there was a lack of detail on the rationale for data inclusion and extraction, assessment of bias and statistical methods used for adjustment.
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The rationale for big data is that, with enough information going in one end, and enough processing power crunching it, insights can be drawn from the flimsiest of foundations.
2. Are the data variables listed in the template clearly defined? 3. Is the rationale for the data variables described?
The main rationale for employing data from cohorts representing different stages of HIV infection was to determine levels and distribution of plasma HIV-1 RNA in the local epidemic, and assess the HIV-1 RNA variability among different populations.
This was the rationale for focusing data collection on the posterior capsule in this model.
TK participated in the study design and coordination, the rationale for the data analyses, and helped to draft the manuscript.
NDB participated in the study design and coordination, the rationale for the data analyses, and helped to draft the manuscript.
HK participated in the study design and coordination, the rationale for the data analyses, carried out the study, and helped to draft the manuscript.
TK participated in the study design and coordination, the rationale for the data analyses, carried out the study, and helped to draft the manuscript.
The rationale for keeping data for this length of time is to allow sufficient time for publication of the research in a peer-reviewed journal and subsequent academic review.
Sound hypotheses must drive the rationale for using individual data or aggregated future teacher data as surrogates for program-level constructs in order to derive correlation coefficients.
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