Our observation that the levels of AKT phosphorylation are increased in MCF7L xenograft tumors after two weeks of Ful treatment provides an additional rationale for combining AKT inhibition with Ful, a combination that should be tested in the clinic.
Based on the rationale for combining a tyrosine kinase inhibitor of VEGFRs with chemotherapy, the combination of sunitinib plus irinotecan might offer efficacy in this patient category.
What was the rationale for combining currencies?
The results might act as a rationale for combining both analgesics.
Taken together, these results provide a strong rationale for combining an immunotoxin with cancer vaccines for the treatment of patients with advanced cancer.
In this context, in-depth investigation on TKI chemosensitizing functions might provide a strong rationale for combining TKIs and conventional therapeutics in specific malignancies.
"The Boards of Worldpay and Vantiv see compelling strategic, commercial and financial rationale for combining Worldpay and Vantiv's complementary businesses," Worldpay noted in a statement issued to the market.
Both approaches show that ETw is not sensitive to soil properties, which provides a rationale for combining historical data from different locations to study the impact of climate variability on evapotranspiration processes at annual time scales.
Announcing Pfizer's new offer, Pfizer chairman and chief executive Ian Read said the firm believed "that there is a highly compelling strategic, business and financial rationale for combining our businesses, with significant benefits for shareholders and stakeholders of both companies".
The results obtained provide a strong rationale for combining RO4987655 with compounds affecting the PI3K/AKT pathway in order to overcome adaptive mechanisms of tumor resistance to MEK inhibition.
Hence, there is a need of finding a trade-off between noise and blur and it provides a rationale for combining the estimation of noise and blur in the same method.
