The appeals court had found that the Netscape browser and Java were only potential threats to the operating system, Mr. Lacovara argued, and since it was impossible to measure how much damage Microsoft had done to competition, there was no rationale for a broad remedy.
The rationale for this broad inclusion of variables in the final models was to maximise control of potential confounding by personal and trip characteristics, to allow comparison of results across severity metrics, and to ensure that characteristics previously shown to be consistently related to injury severity were included in all the models (ie, age, crash circumstance).
Primary GBM, which constitute 90-95% of GBM, differ from non-GBM with respect to a number of molecular characteristics, providing a molecular rationale for these two broad glioma subtypes.
Primary GBM, which constitute 90-95% of GBM [ 9], differ from non-GBM with respect to DNA copy number [ 11], gene expression [ 11], DNA methylation [ 12- 14], and isocitrate dehydrogenase (IDH) 1 or 2 gene mutation status [ 11- 16], providing a molecular rationale for the two broad glioma subtypes of GBM and non-GBM.
Hence inhibiting the eIF4F checkpoint suppresses tumor growth through multiple mechanisms and provides a rationale for development of broad-acting therapeutics.
The threat of terrorism has become the broad rationale for the invasion of our privacy.
Although consent policies are evolving, the underlying rationale for respecting such a broad consent (that is, respect for autonomy) has not been elucidated.
"The broader rationale for stronger growth in 2014-2015 … remains intact.
Placing the submarine activity in the larger context of Russian geopolitical strategy, it is possible to see the broader rationale for these moves at this moment.
This provided a rationale for the development of broad-spectrum matrix metalloproteinase (MMP) inhibitors as a new class of drugs [ 5, 6].
