The main purpose of this article is to review the rationale and phase II/III clinical data for approved and emerging multitargeted agents used in the treatment of solid tumours.
The rationale for Mr Blair's trust, approved in advance by Sir Gordon Downey, the par liamentary commissioner, was to pre-empt accusations of improper influence on the party leader.
Allan Levey (Emory University, Atlanta, GA, USA) presented the rationale for atomoxetine, a norepinephrine transporter inhibitor approved for attention-deficit/hyperactivity disorder to increase norepinephrine levels.
"The rationale for requiring separate audit committee approval of a delisting was to ensure that independent directors approved the decision," said Catherine R. Kinney, president and co-chief operating officer of the Big Board.
If the installation commander, or other designated authority, fails to approve the project request, the rationale for that decision will be provided to the RAB/TRC in writing.
Ana Pereira (Rockefeller University, New York, NY, USA) presented the rationale for a pilot study of riluzole, a glutamate modulator approved to treat amyotrophic lateral sclerosis.
The board was informed of the rationale for using the Whitewing, LJM, and Raptor transactions, and after approving them, received status updates on the entities' operations.
Often, a rationale for the logo is imposed after the logo has been approved.
While both drugs are approved for postexposure prophylaxis [ 14], the rationale for favoring doxycycline was to prevent ciprofloxacin resistance in more common bacteria.
Thus, our findings provide a rationale for phase II/III trials, including combination of atorvastatin with already approved immunomodulatory therapy regimens.
After final refinement of the rationale for each recommendation and the complete manuscript, the updated document was approved by the endorsing organisations between October 2009 and January 2010.
