The methodology for doing systematic reviews is well developed nowadays and well described for instance in the Cochrane handbook for reviewers, but a well founded methodology and rationale for performing a systematic review of reviews is currently lacking, especially with regard to the ways of synthesizing data.
The benefit between the intake of ALA and the reduction in stroke risk in humans, the substantial evidence that ALA reduces infarct size, improves outcome and survival in animal models and the fact that ALA exhibits a wide safety margin provides a strong rationale for the systematic study of ALA administration in stroke.
The present findings provide a clinical and neurobiological rationale for more systematic and detailed analysis of auditory spatial function in Alzheimer's disease, with several avenues for future work.
The rationale for not performing a systematic review to identify other includable studies was that we had access to individual encounter data and sufficient homogeneity of methods and outcomes to be combined, and addition of other studies would add heterogeneity.
In summary, the cases reported here indicate that AI testing should not generally be omitted in total-IgG OCB-negative patients and provides a rationale for systematic and prospective studies on the comparative sensitivity and specificity of AI and total-IgG OCB testing in infectious diseases of the CNS as well as in other indications.
Our findings indicate that AI testing should not generally be omitted in OCB-negative patients and provide a rationale for systematic and prospective studies on the comparative sensitivity and specificity of AI and total-IgG OCB testing in infectious and other diseases of the CNS.
The details and rationale for the systematic approach adopted by this study have been previously published [63].
Finally, we hope we have offered encouraging preliminary rationale for further systematic study of customized music cognition tests as probes of function in dementia syndromes.
51 The rationale for writing systematic reviews of reason-based bioethics may, in some respects, be stronger than in the case of clinical epidemiology: reason-based bioethics is particularly contentious, and the reason-based bioethics literature is especially difficult to retrieve, not only for medical professionals, who are not trained to retrieve it, but also for reference librarians.
