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Overall, these results provide a solid rationale for a future clinical translation.
All these adverse effects were markedly inhibited by the oral administration of NAC, which provides the premise and rationale for a future study on the protective effects of oral NAC in heavy smokers.
Although a causal relationship could not be established due to the retrospective design, we believe that our results provide the rationale for a future randomized trial to validate this observation.
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In addition, it provides a rationale for the future design of potent inhibitors with drug-like properties targeting an inactive form of the enzyme.
These findings provide a rationale for designing future studies to evaluate the chemopreventive potential of GS in ST / nicotine associated head and neck cancer.
These interesting results provide a rationale for the future development of HDAC6 inhibitors to treat patients with solid tumours.
Use of imaging and molecular biochemical biomarkers of pharmacodynamics identified here will provide a rationale for the future development of ICEC-0782.
More importantly, our results provide a rationale for conducting future clinical trials evaluating the effectiveness of using olaparib combined with SAHA to treat TNBC patients.
Our study provides a strong rationale for undertaking future studies to explore the impact of potential corrective actions aiming at reducing ADE-related ICU admissions.
Taken together, our data provide a rationale for future design of retargeted vectors with a safer profile.
The authors concluded that their results may provide a rationale for future clinical application using arenobufagin as a chemotherapeutic agent for the treatment of patients with hepatocarcinoma [ 28].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com