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A better understanding of P2X7R-dependent changes in plasma membrane permeability will allow a rationale development of novel anti-inflammatory and anticancer drugs.
A greater understanding of the cellular mechanisms involved allows design-based solutions for rationale development of safe, effective and clinically relevant polyplex-based RNAi drugs.
Results lay a foundation for a rationale development of new leads from Nijatryp library.
Hence, identification of host and viral proteins that are recruited to cccDNA minichromosomes and suppress its function in response to IFN- α may reveal host and viral targets for rationale development of antiviral drugs to eliminate or transcriptionally silence cccDNA 51, 85.
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This programme is based on the content and behaviour change techniques of the successful Prediabetes Risk Education and Physical Activity Recommendation and Encouragement (PREPARE) programme; a full description of the rationale, development and efficacy of which can be found elsewhere [ 9, 28].
The manuscript introduces the rationale, development, and design of the SIHD and presents a test of the instrument's inter-rater reliability and convergent/discriminant validity.
This article discusses the rationale, development and implementation of the module.
Here we describe the rationale, development, and implementation of a multi-component behavioral intervention targeting patients who have persistently not met goals of CVD risk factor control.
This paper describes the rationale, development, and methods of the Spartners for Heart Health program.
Zavala, F. et al. Rationale for development of a synthetic vaccine against Plasmodium falciparum malaria.
This article will hopefully serve as a platform for designing the advanced TRISO that can minimize the activity release, and providing the rationale of development of the intensive accident mitigation system in future.
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