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(Similarly, Snowden's revelations demonstrated how the government was using legal rationale derived from a case involving old telephone-switch-box technology as justification for collecting cell-phone metadata).
This strategy contradicts the policy rationale derived from Broken Windows theory, and deviates from the original emphasis on communities by focusing on people.
These compounds were identified with receptor-based virtual screening and then chemically optimized on the base of rationale derived from biochemical screening and molecular modeling.
(Similarly, Snowden's revelations demonstrated how the government was using legal rationale derived from a case involving old telephone-switch-box technology as justification for collecting cell-phone metadata). Can the law differentiate between Russian hackers and American dissidents?
However, the development of the interventions primarily built on a theoretical rationale derived from efficacy studies.
This approach has an interesting preclinical rationale derived from studies that have suggested the power to increase tumor growth following withdrawal of VEGF inhibitors.
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Despite promising pathophysiological rationales derived from preclinical trials, most clinical trials of agents that were successful in preclinical trials did not demonstrate improved outcomes in patients with sepsis.
Moreover, if the IATA is based on mechanistic rationale, derived, for example, from knowledge described as an AOP, then the value of the method will be related to its (mechanistic) relevance to key events and the reliability (reproducibility) of the data it generates.
This rationale is derived from human capital theory, which focuses on the economic productivity of individuals over time, and the conditions which enhance it.
These rationales were derived from several group sessions with attending and housestaff physicians where clinical management strategies were discussed.
Most resources advise caution in interpreting these investigations, noting their exploratory nature, but when there is a clearly stated rationale, especially when derived from previous research, and sufficient trials are included, a priori planned investigations may improve applicability.
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CEO of Professional Science Editing for Scientists @ prosciediting.com