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(Similarly, Snowden's revelations demonstrated how the government was using legal rationale derived from a case involving old telephone-switch-box technology as justification for collecting cell-phone metadata).
These compounds were identified with receptor-based virtual screening and then chemically optimized on the base of rationale derived from biochemical screening and molecular modeling.
However, the development of the interventions primarily built on a theoretical rationale derived from efficacy studies.
This approach has an interesting preclinical rationale derived from studies that have suggested the power to increase tumor growth following withdrawal of VEGF inhibitors.
Moreover, if the IATA is based on mechanistic rationale, derived, for example, from knowledge described as an AOP, then the value of the method will be related to its (mechanistic) relevance to key events and the reliability (reproducibility) of the data it generates.
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Despite promising pathophysiological rationales derived from preclinical trials, most clinical trials of agents that were successful in preclinical trials did not demonstrate improved outcomes in patients with sepsis.
This rationale is derived from human capital theory, which focuses on the economic productivity of individuals over time, and the conditions which enhance it.
This procedure is based on the following rationale: Datasets derived by a systematic selection procedure (such as differential gene expression analysis) may be characterized by aggregation indices clearly exceeding the IAs of randomly generated datasets if they show IAs at least one standard deviation above the mean IA of reference datasets with equal numbers of elements.
These rationales were derived from several group sessions with attending and housestaff physicians where clinical management strategies were discussed.
However, the rationale for deriving Eq. 3 remains identical, whatever the time of acquisition (>t* after injection).
The purpose of this paper is to provide the logic and rationale for deriving a residential indoor air concentration for formaldehyde using the most defensible scientific data related to exposures and/or effects reliably associated with this chemical, including both cancer and non-cancer effects.
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CEO of Professional Science Editing for Scientists @ prosciediting.com