The rationale comes, in part, from the recent clinical success of drugs that target multiple kinases.
The Russian account, the first official rationale, came after experts last week offered theories of the failure ranging from a startup glitch to foul play.
That rationale came under fire swiftly on Friday, suggesting that the rule could face a court challenge if it is finalized.
The rationale comes from studies demonstrating that even small or relative increases in serum creatinine are associated with increased patient morbidity and mortality, independently from expected calculated mortality.
His growth rationale comes from a "super-lucky" confluence: The retail market, Amazon's original quarry, is "many trillions," as is, he says, the cloud market that Amazon Web Services (AWS) pioneered.
But after the election he repeatedly declined to simply shut it down, promising that he would find a way to "do something for the kids". Now it appears he may have been putting the program on life support, to be terminated whenever a compelling political rationale came along.
Further rationale comes from mammalian studies where AMPK activity has been shown to regulate the expression of orexigenic transmitters [25].
To count as a plausible treatment at all, there must be some rationale for trying it, with this rationale coming from inferential or analogous reasoning.
With this rationale comes the prediction that high population density would make the alternative tactic (sneaking by minor males) advantageous over a wider range of body sizes, moving the switchpoint for horn production to larger body sizes [ 26, 27].
As noted above, such rationales come into tension with liberal neutrality; further controversy regarding them will be discussed below (5.2).
