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The rationale behind studies of genetics in complex diseases is that identification of gene variants contributing to susceptibility will provide important information concerning the pathogenesis and hopes for future therapy.
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The rationale behind studying microsatellite markers and not single nucleotide polymorphisms was that microsatellite markers evolve faster, and thus might tag an allele that alters the phenotype, whereas ancient single nucleotide polymorphisms may only show a core haplotype.
The rationale behind these studies was that switching to another regimen early in the administration of chemotherapy could overcome drug resistance.
The rationale behind these studies is to test if a single application of tDCS induces immediate gain in the selected outcome measures.
Enhancing the low antioxidant capacity of heart tissue was the rationale behind several studies conducted for the protection against doxorubicin-induced cardiotoxicity (Keizer et al, 1990).
The simple rationale behind these studies was that changing climate should lead to changes in body size as predicted by Bergmann's Rule.
The rationale behind most studies was that orthoses may mitigate the effects of high or low arched feet on the lower limb kinetic chain and so prevent or reduce LBP.
The rationale behind QTL/microarray studies is that causative genes may have polymorphisms causing differences in their level of expression that translate into varying amounts of mRNA and ultimately varying amounts of functional proteins, leading to observable phenotypes.
The rationale behind adaptation studies is that repetition of the same stimulus type results in response suppression which reveals neural populations that are tuned to the processing of a specific stimulus attribute, that is, repetition suppression reveals functional specificity of neural populations.
The rationale behind these studies is to estimate an expected event rate at a specific time of the year for a specific year, and then compare the observed event rate during specific weather conditions to the expected event rate forming a relative risk.
This proposition was the rationale behind this study; we found a need to study the status of vitamin D deficiency amongst Egyptian females and its relation to the glycemic control in pregnant women with GDM, and we aimed at producing recommendations concerning this issue to be implemented in the current Egyptian antenatal care program.
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