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Careful consideration is needed so that several key principles are adhered to, with greater emphasis on preclinical rationale and understanding the biology, real-time molecular profiling and appropriate patient selection, and intelligent clinical trial design that will address the question posed by the novel therapeutic being developed.
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Researchers reading their colleagues' work can have the opportunity of appreciating the elements of the study and understanding the rationale for choosing a particular design and specific measurements.
A clear picture of the force transfer mechanism of the foot and ankle structures can help predicting the loading situation and understanding the biomechanical rationale behind different treatment plans and functional footwear designs.
Thirdly, the identification of gene families provides a base for uncovering and understanding the biological rationale of functional novelty and partitioning following gene duplications.
And understanding.
The theoretical frameworks utilised provide a scientific rationale for understanding how and why the interventions had these effects, improving the reproducibility and generalisability of these findings and offering a sound basis for an intervention in a "real world" trial.
Theory can be considered as a light on social reality – illuminating what is happening and providing a rationale for understanding why it is happening (Tobin 2008).
The rationale for understanding cell anatomy and physiology is due to the fact that disease can arise from cell dysfunction, and any synthetic intervention leads to cells that ultimately encounter these synthetic, hybrid, and transplanted materials.
Analysis of Nank4−7* DSE structural energetics at room temperature as a function of solvent provides rationale for understanding the structural and dimensional effects in terms of how modulation of the solvent alters solvent quality for the peptide backbone.
Computational docking experiments have been used to provide a rationale for understanding the interactions between the larger FPP analogues and the mutant enzymes.
Taken together, these computational results provide a compelling rationale for understanding the behavior of these mutant PFTase variants and suggest that docking experiments should be useful in predicting the effects of mutations as this enzyme is further engineered.
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