An empirical evaluation in several domains supports the theoretical results, and shows that the rational variants, rational lazy A⁎ and rational lazy IDA⁎, are better than their non-rational counterparts.
Selenomethionine-labeled P2OxA was used for X-ray analysis and the resulting crystal structure enabled the rational design using variant P2OxA1 with the substitution E542K as template.
In contrast to random methods (error-prone PCR or DNA shuffling), site-directed mutagenesis enables the rational design of variant libraries and provides control over the nature and frequency of the encoded mutations.
Further molecular characterization of the structure and maturation of these proteins is in progress, aimed at providing information for rational design of variants with desired fluorescence properties.
In this study, rational design afforded a variant of Mycobacterium tuberculosis, Mtb-DHDPS-A204R, with disrupted quaternary structure.
Efforts have focused on the rational engineering of rFVIIa variants with increased hemostatic potential.
Polynomials, and variants like rational functions, truncated power series, and Poisson series, represent an important class of expressions in algebraic manipulation.
By exploiting these advances, we present the CamSol method for the rational design of protein variants with enhanced solubility.
The C1C2 structure has enabled the molecular interpretation of a large volume of electrical and spectroscopic data and allowed the rational design of ChR variants with blue-shifted absorption8 and charge-inverted anion selectivity9,10,11,12.
The rational model and its variants of decision making emphasize recognized phases and sequence among them, while anarchical models focus on the lack of structure and sequence in many real-world decision-making contexts.
