More importantly, our study presents a rational approach to further exploring microRNA profiling data in deciphering the role of microRNA in complex syndromes such as HF.
Though metabolic flux analysis has been somewhat limited in application towards pharmaceutical production, the overall goal is to: (1) have a better understanding of the organism and/or process in question, and (2) provide a rational basis to further engineer (on both metabolic and process scales) improved pharmaceutical production in these organisms.
These are rational combinations to further explore for the treatment of patients with advanced HCC.
Present knowledge, though sparse, is summarized below, highlighting areas that require investigation to enable a rational approach to further research.
It is therefore rational to predict that the further upregulation of HIF-1 α by an anaesthetic would compound or even enhance its effect of promoting malignant behaviour in cancer cells, whereas the use of an agent such as propofol which has been shown to inhibit HIF-1 α activity might prove helpful in bringing about the opposite effect.
In conclusion, a framework was developed that provides a rational basis on which to further the discussion on human biomonitoring and will hopefully lead to the better use and application of this type of data in human health risk assessment.
To further enhance rational design of nanomedicine for overcoming drug resistance, we review the latest thoughts and accomplishments in recent literature.
Unravelling the exact position of sucrose in plant cell-wall invertases is a necessary step towards the rational design of superior invertases to further increase crop yield and biomass production.
With respect to (I), some have argued that despite the fact that Plato's programmatic remarks about the preludes suggest that they are designed to further a rational appreciation of ethical truths, what is actually provided for the vast majority of the citizens is, primarily, rhetorical persuasion appealing to their sense of honor and shame.
The 3D model structure of 3β-HSD_1 has been successfully used for the rational design of mutagenic experiments to further elucidate the key substrate binding residues in the active site as well as the basis for dual function of the 3β-HSD_1 enzyme.
