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Since 30 50% of patients with portal hypertension will bleed from varices and about 20% will die from the effects of the first bleed, it seems rational to develop prophylactic regimens to prevent the development of, and bleeding from, these varices.
Therefore, it is reasonable to initiate protective measures before onset and to prevent further degeneration, once the disease appears and it is rational to develop cell replacement for the lost neurons and glia.
Because tumor suppressor genes such as p53 are not druggable, it is rational to develop anticancer agents for druggable genes which have synthetic lethal interaction with p53.
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To address these challenges, the butanol pathway was engineered into the chromosome in the first place, then the host and the butanol pathway was iteratively engineered through rational and non-rational strategies to develop an efficient butanol producer where the heterologous butanol pathway fits the host well.
Structure function relationship is further discussed, suggesting a rational strategy to develop ladder-conjugated small molecules.
A more rational approach to develop NM formulation would entail a then through understanding of the causes of crystallization and their characterization in a variety of storage conditions.
The tackling of this problem is beset with a lot of shortfalls such as the unavailability of an adequate precipitation theory, lack of sufficient understanding of the process to adopt a rational approach to develop more effective dispersants and inhibitors.
This study not only suggests a theoretical basis for gas-sensing properties of the TiO2-supported Au nanoparticles, but also offers a rational approach to develop nanostructure-based chemical sensors with improved performance.
Both Sims and Sargent built on this idea of "rational expectations" to develop methods that help identify causal links between policy changes and economic events on the one hand, and macroeconomic indicators such as gross domestic product, inflation, and unemployment on the other.
Therefore, this work provides a case study that illustrated a rational approach to develop a science‐based and knowledge‐based process monitoring strategy, which is essential for establishing both a suitable process control strategy and an operational process space for a pharmaceutical unit operation.
Based upon these results we present a rational strategy to develop genes that encode α-gliadins that are safe for consumption by celiac disease patients.
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