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"We will understand the mechanism of disease sufficiently to do rational therapy.
We proposed that the observed intertumoural heterogeneity might have underpowered prior attempts to discover targets for rational therapy.
Still, as more such agents are developed, "it's the beginning of more rational therapy," said Dr. Gregory Burke, global head of development for Novartis's oncology unit.
Group 3 and Group 4 medulloblastomas have generic names as comparatively little is known about their genetic basis, and no targets for rational therapy have been identified7.
Huillard, E. et al. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.
Our approaches help to gain insight into system properties and rational therapy design, as well as to generate hypotheses for further research.
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"This can allow us to develop more rational therapies".
And as our understanding evolves, he predicts that rational therapies will follow.
Our laboratory focuses on understanding the genetic and mechanistic underpinning of photoreceptor degeneration, and developing rational therapies for these blinding conditions.
We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases.
While the notion of synaptic diseases has received much attention, no candidate disorder has been sufficiently investigated to yield new, rational therapies that could be tested in the clinic.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com