Sentence examples for rational target from inspiring English sources

This observation also suggests that BRAF is a rational target for the design of targeted agents to treat melanoma.

The results of this study reveal that the C. parvum SSAT may provide a rational target for drug design.

Clinical programs are increasingly characterized by rational target selection, preclinical optimization of therapeutic molecules, and an emphasis on efficient clinical trial design.

HIV-1 integrase (IN) is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS drugs.

Thus, attention should be directed to the mPTP as a rational target for the development of drugs designed to treat ALS.

Given the fundamental role of L reduction and refolding, this machinery represents a rational target for the development of mechanism-based antitoxins.

This provides a foundation for a rational, target-driven syntheses of metal complexes derived from rigid, tricyclic scaffold ligands.

With the evolution of rational target-based approaches, scientists were able to study the direct interaction of compounds with their intended targets, expecting that this would lead to more-selective and safer therapeutics.

There is little evidence-based information on rational targets and stimulation parameters.

Analysis involves the design and identification of rational targets through application of metabolic flux and control analysis.

We also suggest new possibilities for drug design, based on the rational targeting of these molecular players.