Sentence examples for rational screening from inspiring English sources

The human wild-type (R482) ABCG2-transfected cells were used for rational screening of inhibitory acridones.

A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations.

The idea behind EMICs is clear and straightforward, but the huge pool of variables in its synthesis and characterization requires some rational screening strategies.

The current work implied that rational screening of transient pore-forming polymer in solid dispersion could be a robust approach for controlling hydrophilic drug release.

The aim of this work was to regulate the dissolution of hydrophilic drug from hot-melt extruded solid dispersion via rational screening of the pore-forming agents.

Atom-resolution and time-resolved insights are provided to microscopically and fundamentally elucidate cellulose dissolution/regeneration, which are indispensable in the rational screening and design of new ILs for efficient cellulose pretreatment.

Here, we report on the rational design, screening, and evaluation of an injectable peptide hydrogel as a local losartan depot aiming to inhibit CAFs and potentiate chemotherapy.

The method extends the range of rational drug screening and is helpful for finding new drugs according to the action mechanism [ 16– 20].

36 This could be useful to identify cluster-specific motifs, and a graphical display of secondary structural details can be made for further analysis such as dimer interface prediction (homodimers and heterodimers), ligand-docking, and rational virtual screening of large-scale odor molecules.

Because mutations in PSEN1 are the most frequent cause of EOFAD, it is rational to screen for PSEN1 mutations first, particularly if the patients have early age of onset, followed by APP and PSEN2 mutations [ 118].

Being questioned by airport security as to where I am traveling to, for what purpose and to visit whom, as is the case for travelers in security-intense Israel, is also a rational and reasonable screening method, and I will gladly provide the requested answers.