Sentence examples for rational modifications from inspiring English sources

Further testing and rational modifications of these CMT analogues might lead to new anticancer agents.

Rational modifications to increase cationic charge density and amphipathic helicity engineered mitoparan (MitP), a mitochondriotoxic bioportide and potent secretagogue.

These findings now provide a sound basis for rational modifications to be made to recombinant FPV, designed to improve subsequent vaccine responses.

We propose an empirical model for the ligand structure for rational modifications in new drug design and potentially new lead structures.

Molecular modeling studies using semiempirical AM1 method were made in order to establish rational modifications to optimize them by molecular simplification.

Rational modifications of analogues by introduction of hydrophobic substituents on the aromatic ring has led to more than tenfold increase in antibacterial activity against multidrug resistant Gram positive strains.

It is very important to understand quantitatively the control exerted on the flux for the rational modification of metabolic fluxes.

Ambitious goals that are based on the rational modification of molecular structures functions with relationships by pressure.

Rational modification of lipase specificity may increase the commercial utility of this group of enzymes, but is hindered by insufficient mechanistic understanding.

It is worth mentioning here that a rational modification of a nanoparticle's surfaces not only prevents agglomeration but also guarantees its enhanced biocompatibility, water solubility, and non-specific adsorption to cells (Indira et al. 2010).

Furthermore, the results showed that α,α-disubstituted aziridinemethanols with electron-withdrawing groups led to much higher enantioselectivity than those with electron-donating groups, which allowed the rational modification of catalyst structure to achieve optimal enantioselectivity.