Sentence examples for rational modification from inspiring English sources

It is very important to understand quantitatively the control exerted on the flux for the rational modification of metabolic fluxes.

Ambitious goals that are based on the rational modification of molecular structures functions with relationships by pressure.

Rational modification of lipase specificity may increase the commercial utility of this group of enzymes, but is hindered by insufficient mechanistic understanding.

Furthermore, the results showed that α,α-disubstituted aziridinemethanols with electron-withdrawing groups led to much higher enantioselectivity than those with electron-donating groups, which allowed the rational modification of catalyst structure to achieve optimal enantioselectivity.

Thus, defining molecular determinants of the phenotypic landscape that idling populations occupy may lead to "targeted landscaping" therapies based on rational modification of the landscape to favor basins with greater drug susceptibility.

A series of novel quinoline oxadiazole hybrid compounds was designed based on stepwise rational modification of the lead molecules reported previously, in order to enhance bioactivity and improve druglikeness.

Further testing and rational modifications of these CMT analogues might lead to new anticancer agents.

Rational modifications to increase cationic charge density and amphipathic helicity engineered mitoparan (MitP), a mitochondriotoxic bioportide and potent secretagogue.

We propose an empirical model for the ligand structure for rational modifications in new drug design and potentially new lead structures.

These findings now provide a sound basis for rational modifications to be made to recombinant FPV, designed to improve subsequent vaccine responses.

Molecular modeling studies using semiempirical AM1 method were made in order to establish rational modifications to optimize them by molecular simplification.