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This is only possible when the use of the full potential of the material, the design of load-optimised component geometries, and the use of rational manufacturing procedures is part of an integrated process.
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In 1765 Matthew Boulton opened the Soho Manufactory, pioneering the combination and mechanisation under one roof of previously separate manufacturing activities through a system known as "rational manufacture".
With increasing use of fiber reinforced polymer composites follows a natural pursuit for more rational and effective manufacturing.
The improved understanding of the process of growth and development of ECM in these mechano-sensitive cell-scaffold systems will lead to more rational design and manufacturing of engineered tissues operating under highly demanding mechanical environments.
In this study, we therefore used rational design and additive manufacturing in the form of selective laser melting (SLM) to fabricate porous titanium implants with interconnected pores, resulting in a 3.75 times larger surface area than corresponding solid implants.
Experiments that integrate mtDNA sequencing with metabolic flux analysis and metabolomics have the potential to improve cell line selection and enhance CHO cell metabolic phenotypes for biopharmaceutical manufacturing through rational mitochondrial genome engineering.
In manufacturing systems, the rational base for these decisions is often uncertain information.
Recent progresses in materials templating techniques, including the advent of three-dimensional printing, have accelerated the development of macroscopic architectures with micro-level-controlled features by rational design, with potential for manufacturing.
During drug product development, rational design of the formulation and manufacturing process is essential for achieving the target product profiles and assuring consistent, high-quality products.
Such strength charts should help in the development of more rational standards for handling packaged ICs during manufacturing and integration from the viewpoint of avoiding moisture-related failures.
The revision of bioequivalence guidelines and the enhancement of good manufacturing practice (GMP) requirements facilitate the rational development and manufacturing control of generic formulations.
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