Sentence examples for rational improvements from inspiring English sources

Rational improvements to compounds of this class resulted in single-digit nanomolar enzyme and cellular activity against PLK1, and oral bioavailability.

Recently, the transport of synthetic drug and gene carriers has been investigated quantitatively with real-time particle tracking technology, providing new insight into particle behavior in complex biological environments that is guiding rational improvements in particle design.

However, the knowledge about the bottlenecks of glycerol growth in S. cerevisiae will be a valuable starting point for further rational improvements of these isolates or of already available commercial production strains.

Engineering of key enzymes de novo in heterologous hosts provides one strategy for the rational improvement of enzyme cocktails.

The rational improvement of microbial strains for the production of primary and secondary metabolites ('metabolic engineering') requires a quantitative understanding of microbial metabolism.

These three different approaches represent powerful tools for understanding the molecular basis for lipase enantioselective catalysis and can guide the rational improvement and tailoring of catalyst performance.

We concluded that our simulation model could function as a new tool for the rational improvement and design of metabolic and regulatory networks.

Advances in genetics and molecular biology have provided opportunities for genomic studies of these economically significant organisms and engineering of cultures that focuses on rational improvement of the industrially useful strain.

The objective is to improve the understanding of the efficiency of global resource use in the industrial sector and, with this information, to facilitate the development, prioritization and ultimate implementation of rational improvement options.

We described in a recent work the rational improvement of an esterase from Bacillus sp. BP7 aimed at investigating the efficiency of several esterase variants for enantiomeric resolution of acetate esters of tertiary alcohols.

The final synthesis and assessment of the new chiral catalyst in the asymmetric addition of Et2Zn to benzaldehyde revealed that this necessary relationship guided our design of highly enantioselective ligands or rational improvement of existing ligands by means of knowledge of conformational analysis.